This retrospective study examined the relationship between dose-averaged linear energy transfer (LETd) and local recurrence (LR) in patients with inoperable pancreatic cancer treated with carbon ion radiation therapy (CIRT) at Gunma University. Data from 106 patients treated between 2013 and 2021 with a prescribed dose of 55.2 Gy (RBE) in 12 fractions were analyzed. Using […]
Dose Heterogeneity Reduces Radiation Oxygen Dependence in Both Tumor and Healthy Tissues: The Case of Proton Minibeam Radiation Therapy.
The study investigates whether proton minibeam radiation therapy (pMBRT), characterized by spatially modulated high-dose and low-dose regions, can reduce the oxygen dependence of radiation response in tumors and normal tissues compared with conventional proton therapy (CPT). Using glioblastoma-bearing and healthy rats exposed to different oxygen levels during irradiation, researchers analyzed survival, immune response, and tissue […]
Proceedings of the 2024 National Association for Proton Therapy, Proton Collaborative Group, and Particle Therapy Co-operative Group—North America Proton Therapy Research Forum: Refining Particle Therapy Trial Design and Identifying High-need Areas for Continued Investigation
The article reports on a research forum convened by major proton/particle-therapy associations in North America, aimed at advancing clinical trial design for particle therapy and pinpointing underserved research areas. The forum organizers gathered stakeholders — clinicians, physicists, trialists — to assess current trial methodologies, barriers to trial execution, and strategic priorities. Key discussion points included: […]
Proton Centers in China
As of December 25, 2024, the WeChat public platform “Proton China” has summarized the progress of proton radiotherapy projects in China based on publicly available online information. According to incomplete statistics, there are 49 proton therapy projects in mainland China, including those in operation, under construction, and proposed. A total of 35 medical institutions have […]