The article investigates how variations in breath-hold reproducibility influence dose delivery in stereotactic body radiotherapy (SBRT) for lung cancer, comparing proton and photon treatment techniques. Breath-hold methods, such as deep-inspiration breath-hold (DIBH), are commonly used to reduce tumor motion and spare surrounding healthy tissues. However, small differences in repeated breath-hold positions may affect dose distribution, […]
Quality assurance of the inter-spot beam delivery of a dose driven continuous scanning proton therapy system
The article presents the development and validation of a dedicated quality assurance (QA) program for dose-driven continuous scanning (DDCS) in a synchrotron-based proton therapy system. Unlike conventional discrete spot scanning, DDCS allows continuous beam movement between spots, improving delivery efficiency but introducing complex temporal and dosimetric characteristics that require specific verification. The study focuses on […]
Impact of dose and dose-averaged linear energy transfer on oro-pharyngeal-mucosal toxicity in patients with non-squamous head and neck cancers treated with carbon-ion radiotherapy
The article analyzes the relationship between physical dose, dose-averaged linear energy transfer (LETd), and acute mucosal toxicity in patients undergoing carbon-ion radiotherapy (CIRT). While carbon-ion therapy offers superior dose conformity and higher relative biological effectiveness (RBE) compared with conventional photon therapy, its elevated LET may increase the risk of normal tissue toxicity, particularly in sensitive […]
Relative biological effectiveness and neural stem cell fate in carbon ion–irradiated human brain organoids
The article investigates how carbon ion radiation affects human neural tissue using brain organoids derived from pluripotent stem cells. Carbon ion therapy, increasingly used in advanced radiotherapy, is known for its high linear energy transfer (LET) and greater relative biological effectiveness (RBE) compared with conventional photon radiation. However, its impact on developing human neural stem […]
Updates from the ECR subcommittee
A thrilling ECR workshop, a plenary session as hot as fire, two exciting ECR lunches, outreach initiatives, webinars, and much more. It’s hard to keep the pace, so Early Career Researcher or not, read more about what’s in store! It’s hard to describe the motivation and enthusiasm that the Operative Group of the […]
PTCOG-AO: Where Ancient Wisdom Meets Modern Healing: PTCOG-AO 2026 in Chennai
September 4-6, 2026 | Chennai, Tamil Nadu, India Chennai, the capital of Tamil Nadu on India’s south-eastern coast, has long been a centre of healing and learning. The ancient Tamil medical system flourished here, while the region’s great temples stand as testaments to architectural and scientific precision. Today, this vibrant metropolis, known both as the […]
ELI-Germany Research Workshop on “Innovations and Mechanisms in Radiotherapy”
On January 22–23, 2026, approximately 50 researchers from across Germany, together with representatives of ELI – Extreme Light Infrastructure, gathered at the Centre for Advanced Laser Applications in Munich for a joint workshop organized by the Chair of Medical Physics at Ludwig-Maximilians-Universität München and the ELI leadership. The meeting aimed to stimulate a vibrant exchange […]
R and D Progress on China’s First Light Ion Therapy Device
The successful development of China’s first light ion therapy device marks a major breakthrough in the domestic high-end radiotherapy equipment technology. The therapy device, independently developed and manufactured by CAS Ion Medical Technology Co., Ltd. (CASHIM), has been successfully installed in the commissioning factory of its Hangzhou R&D center. Having completed the critical equipment […]
Particle Therapy MasterClass PTMC
The Particle Therapy MasterClass (PTMC) project celebrated its fifth anniversary in 2025. Since its inception, a total of 70 institutes from 38 countries have performed the PTMC at least once, providing participants with the opportunity to familiarise themselves with methods of treating cancerous tumours using X-rays, protons, carbon ions and, more recently, helium ions. Building […]
The Penn Radiation Medicine Institute: Global Education and Consultancy Services
With more than a decade of experience, The University of Pennsylvania’s Department of Radiation Oncology provides a comprehensive, one-week program offered twice annually in the spring and winter. The course is designed to maximize the onsite experience by delivering a core curriculum while allowing room for customization based on role responsibilities and disease-site interests. The […]