This prospective clinical trial evaluated the feasibility, safety, and dosimetric benefits of upright image-guided proton therapy (IGPT) for patients with recurrent head and neck or brain malignancies. Conducted at the Mayo Clinic, the study included 25 patients treated between 2021 and 2024 using a novel upright positioning system integrated with image guidance and pencil beam […]
Proton therapy for adult-type IDH-mutated glioma: Proglio-1, a multicenter retrospective study
This multicenter retrospective study, conducted under the French PROGLIO-1 project, evaluated the clinical outcomes and toxicity profile of proton therapy (PT) in patients with adult-type IDH-mutated glioma. Given the typically long survival and treatment-related neurocognitive risks in this population, PT’s dose conformity and normal tissue sparing offer potential advantages over conventional photon radiotherapy. Data were […]
Radiation protection in proton therapy: Insights from a multi-institutional survey and experimental measurements within the SINFONIA project
This study, part of the EU-funded SINFONIA project, investigates radiation protection practices in European proton therapy (PT) centers through a multi-institutional survey and experimental neutron dose measurements. The aim was to assess whether current safety protocols may under- or overprotect staff and to validate monitoring practices with quantitative data. Seventeen of 23 PT centers responded […]
Low Dose-Averaged Linear Energy Transfer Contributes to Local Recurrence of Pancreatic Cancer Treated With Carbon Ion Radiation Therapy
This retrospective study examined the relationship between dose-averaged linear energy transfer (LETd) and local recurrence (LR) in patients with inoperable pancreatic cancer treated with carbon ion radiation therapy (CIRT) at Gunma University. Data from 106 patients treated between 2013 and 2021 with a prescribed dose of 55.2 Gy (RBE) in 12 fractions were analyzed. Using […]
Dose Heterogeneity Reduces Radiation Oxygen Dependence in Both Tumor and Healthy Tissues: The Case of Proton Minibeam Radiation Therapy.
The study investigates whether proton minibeam radiation therapy (pMBRT), characterized by spatially modulated high-dose and low-dose regions, can reduce the oxygen dependence of radiation response in tumors and normal tissues compared with conventional proton therapy (CPT). Using glioblastoma-bearing and healthy rats exposed to different oxygen levels during irradiation, researchers analyzed survival, immune response, and tissue […]
Proceedings of the 2024 National Association for Proton Therapy, Proton Collaborative Group, and Particle Therapy Co-operative Group—North America Proton Therapy Research Forum: Refining Particle Therapy Trial Design and Identifying High-need Areas for Continued Investigation
The article reports on a research forum convened by major proton/particle-therapy associations in North America, aimed at advancing clinical trial design for particle therapy and pinpointing underserved research areas. The forum organizers gathered stakeholders — clinicians, physicists, trialists — to assess current trial methodologies, barriers to trial execution, and strategic priorities. Key discussion points included: […]
Proton Centers in China
As of December 25, 2024, the WeChat public platform “Proton China” has summarized the progress of proton radiotherapy projects in China based on publicly available online information. According to incomplete statistics, there are 49 proton therapy projects in mainland China, including those in operation, under construction, and proposed. A total of 35 medical institutions have […]